Pathway Mechanisms
Professor Adrian Wells
Chief Investigator
2-year project
study name
Pathway Mechanisms
Study participants were heart disease patients with comorbid anxiety/depression symptoms referred to CR services at seven NHS Trusts in the North West and took part in the MCT-PATHWAY study.
Study Participants
- The study is a mechanistic study using data from the NIHR-funded PGfAR PATHWAY study.
- PATHWAY was completed in August 2021 and included two RCTs.
- The first RCT (WS2) was a multicentre, two-arm, single-blind RCT with four-month and twelve-month follow-ups comparing Group-MCT plus usual CR with usual CR alone.
- The second RCT (WS3) was a multicentre, two-arm, single-blind RCT with a four-month follow-up comparing home-based MCT plus usual CR with usual CR alone.
Pathway Mechanisms Info
- Depression and anxiety (distress) affect at least I in 3 patients attending cardiac rehabilitation (CR).
- Talking-based therapies are not routinely offered and when available, have limited effects.
- This is concerning because distressed patients are at greater risk of death, further cardiac events, poorer quality of life, and use more healthcare services.
- Our previous studies found that adding a talking-based therapy called metacognitive therapy (MCT for short) to CR significantly reduced distress.
- We need to understand more about why MCT works, who it works best for, and which of the MCT techniques are most successful.
- This will allow us to understand why treatment might fail for some people, which techniques need to be improved and which shouldn’t be changed.
Project Timeline
Stage 1
Months 1-3 will be for study initiation including the creation of databases.
Stage 2
Months 3-19 will be for data cleaning and data analyses.
Stage 3
Months 19-24 will be for report writing and dissemination.
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